Question

Which of the following enzymes catalyzes an irreversible step of gluconeogenesis? Phosphoglucomutase Glucose-6-Phosphatase Pyruvate Kinase Glyceraldehyde-3-Phosphate...

Which of the following enzymes catalyzes an irreversible step of gluconeogenesis?

Phosphoglucomutase

Glucose-6-Phosphatase

Pyruvate Kinase

Glyceraldehyde-3-Phosphate Dehydrogenase

Homework Answers

Answer #1

Glucose- 6-phosphatase is the correct option.

Gluconeogenesis is a process of glucose formation from non carbohydrate molecules such as amino acids, lactate, pyruvate etc.

Glucose 6-phosphatase catalyses last step of the Gluconeogenesis. It irreversibly converts glucose-6-phosphate into free glucose and phosphate group. This step is an irreversible step of the Gluconeogenesis.

Other irreversible steps are catalysed by the pyruvate carboxylase, phosphoenolpyruvate carboxykinase, fructose 1,6-bisphosphatase during the Gluconeogenesis.

Pyruvate kinase is not an enzyme of Gluconeogenesis.

Phosphoglucomutase is involved in starch synthesis.

Glyceraldehyde-3-Phosphate Dehydrogenase catalyses reversible reaction.

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