Which of the following enzymes catalyzes an irreversible step of gluconeogenesis?
Phosphoglucomutase
Glucose-6-Phosphatase
Pyruvate Kinase
Glyceraldehyde-3-Phosphate Dehydrogenase
Glucose- 6-phosphatase is the correct option.
Gluconeogenesis is a process of glucose formation from non
carbohydrate molecules such as amino acids, lactate, pyruvate
etc.
Glucose 6-phosphatase catalyses last step of the Gluconeogenesis.
It irreversibly converts glucose-6-phosphate into free glucose and
phosphate group. This step is an irreversible step of the
Gluconeogenesis.
Other irreversible steps are catalysed by the pyruvate carboxylase, phosphoenolpyruvate carboxykinase, fructose 1,6-bisphosphatase during the Gluconeogenesis.
Pyruvate kinase is not an enzyme of Gluconeogenesis.
Phosphoglucomutase is involved in starch synthesis.
Glyceraldehyde-3-Phosphate Dehydrogenase catalyses reversible reaction.
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