Question

Explain pi-pi interactions and effects to self-assembly of proteins.

Answer 1

A)Pi pi interactions between aromatic rings are recognized to play an important role in the structural stability of protein and DNA and recognition motifs in proteins and enzymes.

A systemic analysis of each pi pi interaction forming residue was performed based on their location in different secondary structure.

B)

The precise incorporation of functional residues into sequences allows for tailoring the noncovalent interactions between peptides to guide their self-assembly into well-defined nanostructures, thus facilitating creation of artificial functional materials resembling natural systems. Here, we report on the self-assembly of dipeptides consisting of one fluorinated phenylalanine unit and one natural aromatic residue into laminated nanofibers predominately driven by polar−π interactions.