Question

An individual after has over 15 years of persistent opioid use (i.e. a long-term addictive behavior). Below are statements about gene expression related to the dopamine pathway in this individual. For each of the statements, indicate whether the statement is TRUE or FALSE, and if you indicate the statement is FALSE, give a 1-sentence explanation of why it is false.

Statement #1: Increased gene expression of the gene encoding the dopamine re-uptake transporter protein, leading to higher amounts of dopamine in the synapse_____________ (TRUE or FALSE - and why)

Statement #2: Reduced gene expression of the gene encoding the dopamine re-uptake transporter protein, leading to lower dopamine re-uptake transporter levels in pre-synaptic neurons _____________ (TRUE or FALSE - and why)

Statement #3: Increased gene expression of the gene encoding the dopamine receptor protein, leading to higher dopamine receptor levels in post-synaptic neurons_____________ (TRUE or FALSE - and why)

Statement #4: Decreased gene expression of the gene encoding the dopamine receptor protein, leading to lower dopamine receptor levels in post-synaptic neurons_____________ (TRUE or FALSE - and why)

Statement #5: Reduced gene expression of the gene encoding dopamine _____________ (TRUE or FALSE - and why)

Answer 1