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1. Answer the following questions regaridng LMO2: A) What is LMO2? B) What is LMO2's role...

1. Answer the following questions regaridng LMO2:
A) What is LMO2?
B) What is LMO2's role in T-cell acute lymphoblastic leukemia?
C) Is LMO2 good or bad in leukemia?
D) When and how was LMO2 discovered?
E) Draw a diagram of the regulation of LMO2 in leukemia

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Answer #1

A. LIM domain only 2 (LMO2) is a protein in human have a two LIM domain that are cysteine rich. This protein is responsible for erythropoiesis in yolk sac. This protein is highly conserved.

B. LMO2 act as a oncogene (responsible for causing cancer) in T-cell acute lymphoblastic leukemia.

C. LMO2 act as a bad for T-cell acute lymphoblastic leukemia as it act as oncogene.

D. LMO2 gene was discovered in year 1990 by Royer-Pokora B, Loos U, Ludwig WD. It was discovered through filter hybridization experiments that was performed to uncover extra genes homologous to LMO1

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