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The following question refers to regulated enzymes in glycolysis. Here is a summary of these enzymes....

The following question refers to regulated enzymes in glycolysis.

Here is a summary of these enzymes.
glycolysis reaction #1 is catalyzed by hexokinase
glycolysis reaction #3 is catalyzed by phosphofructokinase (PFK)
glycolysis reaction #10 is catalyzed by pyruvate kinase

Which of the following statements about glycolysis regulation in liver cells is/are TRUE?

All of the statements are true

Liver hexokinase has a very low Km compared to muscle hexokinase

Liver pyruvate kinase is activated allosterically by a glycolysis intermediate.

Liver PFK has low enzyme activity when insulin is present

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Answer #1

The statements which are true are as follows:

  1. Liver hexokinase has a very low Km compared to muscle hexokinase.
  2. Liver pyruvate kinase is activated allosterically by a glycolysis intermediate.

The statement which is false is " Liver PFK has low enzyme activity when insulin is present". The fact is that in presence of insulin, the enzymatic activity of PFK is increased, whereas glucagon causes lowering of enzymatic activity of PFK enzyme in liver.

Therefore, only 2 statements are true.

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