Question

DNA binding motifs found in transcription factors:

		Almost always bind DNA non-specifically
		Are usually stable enough to fold on their own
		Intercalate between DNA base pairs
		Most often interact with DNA on the major groove side

Answer 1

The DNA binding motifs found in transcription factor always binds to DNA specifically. This means that the DNA binding motifs have specific amino acids to recognize specific base pairs in the DNA.

The correct answer is-

D- most often interact with DNA on the major groove side.

This is because the major groove side of the DNA exposes the bases which are specifically recognized by the DNA binding motifs found in transcription factor. Thus the DNA binding motifs interact with the DNA on the major groove to bind to the DNA.