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Question number 5: Enzymatic control explain how the mutation in phosphofructokinase, affects the allosteric site for...

Question number 5: Enzymatic control

explain how the mutation in phosphofructokinase, affects the allosteric site for attaching ATP will affect the activity of the enzyme in the following conditions:

a. when ATP levels are low in the cell.

b. when ATP levels are high in the cell.

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Answer #1

Phospho-fructokinase or PFK is an important metabolic enzyme which regulates the bioconversion of fructose-1-phosphate to fructose-1,-biphoshpate by consuming ATP. The enzyme undergoes allosteric activation when ADP binds to it. Hence, low levels of ATP promote enzymatic activity, thereby increasing rate of glycolysis and overall increase in cellular ATP pool. Thus, any mutation resulting in disruption of this allosteric binding site will have direct effects on the enzyme activity depending upon the cellular ATP pool.

Answer a: As the mutation makes the enzyme unable to attach to ATP, it will tend to bind the substrate with ATP and hence the rate of glycolysis will increase.

Answer b: Under low ATP abundance, the enzyme having impaired binding site will fail to bind to to ATP again and hence the rate of glycolysis will decrease.

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