Question 3: thioester bonds
a. describe 2 examples of thioester bonds that are high in energy in cell respiration.
b. what are the enzymes that are involved in making thioester bonds?
c. explain what the hydrolysis of these bonds allows (like what we can achieve by this hyddrolysis)
(translated from an other language, let me know if something isn't clear..)
thanks!
A. (R–S–CO–R) Is the compound Structure of Thioester, Its is
well known and important compound in Biochemistry. Coenzyme A,
Acetyl-CoA, Are the two most important co-enzymes which are used
cell repiration.
B. Malonyl-CoA, Acetoacetyl-CoA, Propionyl-CoA, and Cinnamoyl-CoA,
these are the essential enzymes which are involved in formation of
thioester bond.
C. Hydrolyses in Thioester by Hydroxymethylglutaryl-CoA catalyzes
and formation of 3-hydroxy-3-methylglutaryl-CoA by the condensation
of acetyl-CoA by help of acetoacetyl-CoA, thiolases acting as the
electrophile, the acetyl–enzyme intermediate is deprotonated by a
glutamate by acting as base to turn it into the enolate nucleophile
which attacks ketone of acetoacetyl-CoA. This reactivity pattern
enable formation of hydrolysis in Thioester
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