Question

How have our perceptions of cancer development changed? Should we be targeting the “Hallmarks of Cancer” by Hanahan and Weinberg that define cancer (sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis), or should the focus be on targeting enabling characteristics that may set the stage for tumor development? Please explain all details, thank you

Answer 1

Cancer is developed by problems in the gene. When there is uncontrollable cell division cancer forms. This state is known as metastasis. Normal cell do not die and divide uncontrollably forms tumor the stage of tumor varies on case to case basis.

I think we should focus on Hallmarks of cancers because targeted gene therapy is based on specific genes. Tumor suppressor gene P53 gene activity should be normal other cancer causing should be targeted and make normal.

Other than six exsisting hallmarks Hanahan and Weinberg proposed 4new hallmarks to be targeted for cancer therapy.

Abnormal metabolic pathway, evading immune system, genome stability and inflammation are the newly added hallmarks. All these targets covers almost all aspects of cancer so this this targets are better.