Question

describe the livers role and how it converts lipoproteins in the blood?

Answer 1

Liver is known to play a central role in the regulation of synthesis , degradation and storage of lipids and of lipoproteins. Several diseases including atherosclerosis, cholethiasis can be attributed to disturbances in one or more of this metabolic pathways. Carbohydrate fat and protein metabolism are done in liver.

After entry in the blood stream the chylomicrons are hydrolyzed by the endothelial-bound lipoprotein lipase. The chylomicron remnants are rapidly taken up into the liver via the LDL receptor and the LDL receptor-related protein.The liver utilizes the exogenous fat and can release much more lipids via VLDL into the blood. The VLDL are another substrate for lipoprotein lipase. The remaining VLDL remnants can either be taken up into the liver or are hydrolyzed to LDL. LDL delivers cholesterol to all body cells via the LDL receptor.