Question

Why is sickle cell less severe in people of Indian descent compared to those of African descent?

	A) The hemoglobin of people of Indian descent binds 2,3 BPG more tightly
	B) The hemoglobin people of Indian descent have a Glu to Phe mutation
	C) The blood people of Indian descent contain 20- 30% fetal hemoglobin which resists sickling
	D) The hemoglobin of people of Indian descent behaves like myoglobin

Answer 1

Answer:

C) The blood people of Indian descent contain 20- 30% fetal hemoglobin which resists sickling

Explanation:

Sickle cells contains abnormal hemoglobin which is called as sickle hemoglobin that causes the cells in a sickle shape..

A person inherits two copies of beta-globin gene which is required to produce normal hemoglobin. But a sickle cell inherits one normal and one abnormal allele and abnormal inherits encoding hemoglobin S. Therefore, sickle cell disease do not deliver oxygen to the tissues efficiently.

Fetal hemoglobin (HbF) change the phenotype of sickle cell anemia. This modulation is done by inhibiting deoxy sickle hemoglobin polymerization. Therefore, Fetal hemoglobin will not be sickle and thus transport oxygen efficiently.
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