Question

The presence of a noncompetitive inhibitor: 0 leads to a decrease in Km and V o...



The presence of a noncompetitive inhibitor:

0 leads to a decrease in Km and V

o increases the steady-state concentration of the enzyme substrate complex [ES].Э

leads to an increase in Km without affecting V max·

0 leads to both, an increase in the Vmax of a reaction and an increase in the Km·

0 leads toa decrease in the observed Vmax·

Homework Answers

Answer #1

Ans. Lead to a decrease in observed Vmax.

Non-competitive inhibitors don't compete with [S] for active site but bind to substrate to site other than active site. So Km remains unchanged. And V​​​​​max is decreased.

Km is a measure of affinity of enzyme for its substrate.

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