Question

redict the effect of the addition of phosphate groups to threonine residues of a histone on the activity level of gene transcription. (Hint: Think about the logic behind acetylation of lysine residues.) Group of answer choices less active no difference more active

Answer 1

More active

Phosphorylation is a type of histone modification in which phosphate group is added to serine, threonine, tyrosine or histidine amino acid of histone proteins.

Phosphate groups are added by enzymes called as kinases and removed by enzyme called as phosphatases.

In general phosphorylation leads to the loosening of chromatin thereby increasing its accessibility for transcription factors and RNA polymerase and hence increasing the rate of transcription of the genes associated with it. So in this case also, if the phosphate group is added, then the rate of transcription of the gene will increase and it will become more active.

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