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The disease bullies pemohugoid results in the distruction of protein within the basement membrane that hold...

The disease bullies pemohugoid results in the distruction of protein within the basement membrane that hold the epidermis and dermis together . How would this likely impact the epidermis ?woud the skin be an effective barrier with the disease
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Bullous pemphigoid is a chronic autoimmune skin disorder manifested by presence of blisters on skin more commonly in flexor area, lower abdomen and thighs. It is characterized by presence of anti hemidesmosome antibodies. Desmsome is an intracellular structure that holds the epidermis and dermis thus providing strength to the tissue, if desmosomes are destroyed fluid accumulation started in between tissues resulting in forming blisters..

No certainly not with this disease skin wouldn't be an effective barrier as tensile strength of tissue os lost it can be easily breached often leads to skin infections or even generalized sepsis (systemic infection) in some cases. Thanks

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