Rette syndrome is mainly caused by the mutationin MECP2 gene which codes for mecp2 protein needed for the development of brain function and nervous system. Mutation chnages the little production of this protein or you can say that production in less quatity that is not sufficient.
Population genetics aspect: Rette syndrome is a genetic disorder and are very rare in population.less than 1% recorded cases are only inheritaed. It is mainly sporadic that is mutation occur randomly butnot inherited. if more than one family member have this disorder then this disorder follow the dominant X-linked pattern.
Rette syndrom follow this pattern for X-linked dominant inheritance .
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