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What are common aspects and differences in germ cell specification and migration in C. elegans, Drosophila...

What are common aspects and differences in germ cell specification and migration in C. elegans, Drosophila and mammals

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In drosophila, three localised RNAs germ cell less, nanos and polar granule component were implicated in early events of germ cell specifications and transcriptional repression. Functions of nos and pum were not restricted to early specifications but in turn it is required for germ line development whereas Pgc RNA doesn’t have roles in later stages of germ cell development. The active germ cell migration is initiated by crossing of midgut epithelium. Endoderm 1 was required for trans epithelial migration of germ cells which acts in germ cells specifically.

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