Question

You solved a crystal structure of an inhibitor bound to its protein target, and you were interested to discover that at the same time, the substrate was bound in the active site of the target. What type(s) of inhibitor might you have? *

A Competitive or uncompetitive

B Uncompetitive or noncompetitive

C Noncompetitive

D Competitive

Answer 1

Answer: B Uncompeitive or noncompetitive

Inhibition is a process in which inhibitor binds to the enzyme to stop or reduce its enzymatic activity. In uncompetitive inhibition, the inhibitor bind to the different site than an active site but the enzyme should be in the enzyme-substrate complex. In the case of noncompetitive inhibition, the inhibitor also binds to a different site other than the active site but here enzyme-substrate complex is not needed.

In the given case above the inhibitor binds to a different site as the substrate is bounded in the active site so it can be either non-competitive or uncompetitive inhibitor.