Question

Compare and contrast serine proteases and aspartic proteases. Not all answers will be used. Serine protease Both Aspartic protease

Answer 1

Aspartic proteases	Serine proteases
Protease enzyme that bounds to aspirate residues to catalyze their peptide substrates	These proteases cleave peptide bonds in proteins. Serine serve as nucleophilic amino acid at the active site of enzyme
Active at acidic pH	Active for pH range of 3 to 12. Highly active in pH ranges 7 to 12
Consists of two highly conserved aspartates	Main substrates are - peptide bonds with N-terminal and tryptophan, tyrosine, phenylalanine, or leucine
Found in eukaryotes	Found in both eukaryotes and prokaryotes