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Describe the nitric oxide signal pathway in detail. Include upstream to when and where NO is...

Describe the nitric oxide signal pathway in detail. Include upstream to when and where NO is generated and why to downstream where Viagra would have its effects. Include potential nitro glycerine complications.

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Answer #1

The Nitric oxide (NO) is synthesised from L-argenine with the help of enzyme nitric oxide synthase. It's synthetic pathway is described in detail in the following diagram.

Sildenafil (viagara) inhibits the enzyme phosphodiesterase-5 which degrades cGMP in the corpus cavernosum of peniss. Therefore blood vessels dilate resulting in increased blood flow to the penile region.

Side effects of potential nitroglycerine compounds include irregular heart beat, hypotension, tinnitus, sudden visual loss, chest pain and general fatigue.

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