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Achondroplasia is a type of dwarfism cause by an autosomal dominant allele. If a heterozygous acondroplastic dwarf has a child with another heterozygous acondroplastic dwarf what would be the chance of producing an offspring with Achondroplasia?
Answer-
Let dominant allele for achondroplasia be A
Recessive allele for achondroplasia be a
Heterozygous achondroplasic parents ,will be Aa
Parents - Aa x Aa
F1-
A | a | |
A | AA | Aa |
a | Aa | aa |
There is 3/4 or 75% chance of producing an offspring with achondroplasia.
Since it is Autosomal dominant ,it will be inherited both in homozygous dominanant and Heterozygous genotypes.
1/4 or 25% chances of offspring being unaffected m the Genotype would be homozygous recessive - aa.
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