Describe in detail what happens in a gustatory cell when PTC binds the G-protein coupled receptor TAS2R38.
TAS2R38 is a gustatory protein which has the ability to recognize the gustation of phenylthiocarbamate.
This is mediated through a Gprotein coupled reaction(gustducin).When the PTC binds to the receptors Of TAS2R8 (T2R/TRB) the transduction if the signal in the identification of the bitter taste starts.The reception activation of the heterotromers of gustducin occurs .This further operates two pathways
a)Cause the reduction in cNMP levels which is mediated by the alpha subunit of gustducin
b) Beta subunit casuing the increase Inositol-3 - phosphate and diacylglycerol (IP3 and DAG)
The decreases cNMP levels may cause the activity of ion channels for protein kinases and the increased IP3 and DAG will bring about the gustation by causing the release of calcium ions which in turn releases the neurotransmitters.
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