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A culture of mouse fibroblast is prepared and an inhibitor against myosin II is added to...

A culture of mouse fibroblast is prepared and an inhibitor against myosin II is added to the cells. Which of the following processes are these cells to carry out ?

a. separation of chromosomes during mitosis

b. cytokinesis

c.separation of chromosomes during mitosis and formation of lamellipodia

d. separation of chromosomes during mitosis and cytokinesis

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Answer #1

Molecular motors transport cargo within cells along microtubules (kinesin, dynein). They can also slide two actin filaments along each other (myosin) during muscle contraction. Myosin II is a actin binding molecular motor, which interacts and modifies the actin cytoskeleton.

Myosin II is involved in cytokinesis, as it is require for formation of contractile cleavage furrow. However, myosin II is not required for segregation of chromosomes during mitosis.

Lamellipodia are thin, sheet-like membrane protrusions present in front of motile cells. These structures have a dense and dynamic network of actin filaments. Actin polymerization is required for formation of lamellipodia. However, extension of lamellipodia during motility requires myosin II (retrograde flow).

Right option is c. separation of chromosomes during mitosis and formation of lamellipodia.

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