Question

. What are post translational modifications? What purpose do they serve? Give at least 3 examples.

. What are post translational modifications? What purpose do they serve? Give at least 3 examples.

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Answer #1

POST TRANSLATIONAL MODIFICATIONS ARE MODIFICATIONS OF PROTEINS FOLLOWING PROTEIN SYNTHESIS. PROTEINS ARE CHAIN OF AMINOACIDS JOINED BY POLYPEPTIDE BONDS. PROTEINS ARE SYNTHESISED BY TRANSLATING MESSENGER RNA IN THE CYTOSOL OF THE CELL BY RIBOSOMES.

POST TRANSLATIONAL MODIFICATIONS REFERS TO CHEMICAL CHANGES A PROTEIN UNDERGO AFTER TRANSLATION. THESE CHANGES HELP THE PROTEIN TO DO SPECIFIC FUNCTIONS IN THE BODY. FOR EXAMPLE POSTTRANSLATIONAL MODIFICATIONS PLAY AN IMPORTANT ROLE IN REGULATING THE FOLDING OF PROTEINS , REGULATE THE INERACTION OF PROTEINS WITH OTHER PROTEINS , REGULATE THE FUNCTIONAL STATE OF THE PROTEINS SUCH AS ITS CATALYTIC ACTIVITY IN THE CASE OF ENZYMES , REGULATES THE SIGNALLING FUNCTION OF PROTEINS. ETC.

EXAMPLES OF POST TRANSLATIONAL MODIFICATIONS ARE PHOSPHORYLATION , AMIDATION , DEAMIDATION , ACETYLATION , METHYLATION , OXIDATION , HYDROXYLATION , AND FORMYLATION

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