Question

Which of the following may happen if a gene is affected by a null mutation?

a) No mRNA is produced from the gene.

b) The gene contains a premature stop codon.

c) The full-length protein is produced but it completely lost its activity.

d) All of the above.

Which of the scenarios from the question ABOVE can possibly apply to a hypomorphic mutation? ( PLEASE GIVE A DETAIL EXPLANATION)

Answer 1

Which of the following may happen if a gene is affected by a null mutation?

d) All of the above

Null mutation in a gene that leads no transcription to form RNA or translated into a non-functional protein product.

Hypomorphic mutation causes a partial loss of gene function. From the question above, it can be concluded that the option B) The gene contains a premature stop codon possibly apply to a hypomorphic mutation. In hypomorphic mutation, altered gene product possesses a reduced level of activity, but not a complete loss. So, mRNA and protein is produced but altered gene may contain a premature stop codon that leads to a reduced level of activity.