The enzymes of the TCA cycle function in a multistep catalytic irreversible cycle to oxidize an acetyl group to two CO2 molecules with the concomitant generation of three NADPH, one FADH2 and one ATP. The CO2 molecules in a given turn of the citric acid cycle are derived from the acetyl group that entered the same turn of the cycle. The pyruvate that enters the mitochondrial is either to be decarboxylated by a vitamin B7 dependent enzyme or to be carboxylated to oxaloacetate by the same enzyme to enter the gluconeogenesis pathway.
Answer:
The enzymes of the TCA cycle function in a multistep catalytic irreversible cycle to oxidize an acetyl group to two CO2 molecules with the concomitant generation of three NADPH, one FADH2 and one ATP. The CO2 molecules in a given turn of the citric acid cycle are derived from the acetyl group that entered the same turn of the cycle. The pyruvate dehydrogenase that enters the mitochondrial matrix is either to be decarboxylated by a vitamin B7 dependent enzyme or to be carboxylated to oxaloacetate by the same enzyme to enter the gluconeogenesis pathway.
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