Yes . Free zinc would also act as a pro-oxidant. Zn2+ have direct prooxidation and direct anti-oxidation capacity. Metallothionein enzyme can be induced by Zn2+. Under oxidative stress conditions, a zinc dependant transcription factor, MTF-1 can activate metallothionein and protoect cells from oxidative stress. Not only this, as a component of superoxide dismutase, Zn2+ is important in converting superoxide into normal oxygen molecule. Other than this functions, Zn2+ is involved in protection of sulhydryl group in proteins, stabilization of Zinc-fingure protein and lipid peroxidation.
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