Question

Iron, zinc, and copper all function as part of antioxidant enzymes to combat oxidative stress. On...

  1. Iron, zinc, and copper all function as part of antioxidant enzymes to combat oxidative stress. On the other hand, free (unbound) iron and copper can also act as pro-oxidants. Do you think that free zinc would also act as a pro-oxidant? Explain why or why not in 2-3 sentences.

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Answer #1

Yes . Free zinc would also act as a pro-oxidant. Zn2+ have direct prooxidation and direct anti-oxidation capacity. Metallothionein enzyme can be induced by Zn2+. Under oxidative stress conditions, a zinc dependant transcription factor, MTF-1 can activate metallothionein and protoect cells from oxidative stress. Not only this, as a component of superoxide dismutase, Zn2+ is important in converting superoxide  into normal oxygen molecule. Other than this functions, Zn2+ is involved in protection of sulhydryl group in proteins, stabilization of Zinc-fingure protein and lipid peroxidation.

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