Question

46. Many receptors for growth factors are:

Group of answer choices

a. G protein linked receptors

b. ion channel linked receptors

c. associated with tyrosine kinase

d. calmodulin linked receptors

e. IP3 linked receptors

Answer 1

ANSWER :- C and d.

Associated with tyrosine kinase and and calmodulin linked receptor.

• Growth receptors is a receptor that bonds to a growth factor. Majority of growth factor receptors consist of receptor tyrosine kinase(RTKs). The extracelluar domain region where a ligand binds, usually with very high specificity. In RTKs, the binding of ligand to the extracelluar ligand binding sites leads to autophosphorylation of tyrosine residues in the intracellular domain.These phosphorylation allow for other intracellular proteins to bind to with the phosphotyrosine-binding domain which result in a series of physiological responses within a cell.
• Calmodulin linked receptor or calmodulin-binding protein is a epidermal growth factor receptor and is a member of the tyrosine kinase family involved in signal transduction and the regulation of cellular proliferation and differentiation.