Determine how many molecules of glucose is needed for 1 molecule of palmitate (C16). Assume that all NADPH consumed in this process is also produced from glucose using the pentose phosphate pathway in which all glucose 6-phosphate entering the PPP is converted to CO2, , H2O, and NADPH (no ribose 5-phosphate is formed). Required ATP should also be synthesized from glucose.
we know that palmitate is a 16 carbon fatty acid. and its biosynthesis requires Acetyl CoA. glucose gave 2 molecules of Acetyl CoA during glycolysis.
so we require 8 molecules of Acetyl CoA or 4 molecules of glucose.
the reaction is as follows-
First, the formation of seven malonyl-CoA molecules
7 Acetyl-CoA + 7CO2 + 7ATP --------------> 7 malonyl-CoA + 7ADP + 7Pi
then seven reactions cycle of condensation and reduction
Acetyl-CoA + 7 malonyl-CoA + l4NADPH + 14H+ ---------------> Palmitate + 7C02 + 8CoA + l4NADP+ + 6H2O
The overall reaction process is-
8 Acetyl-CoA + 7ATP + l4NADPH + 14H+ ----------------> Palmitate + 8CoA + 6H2O + 7ADP + 7Pi + l4NADP+
Get Answers For Free
Most questions answered within 1 hours.