Question

Explain in details what histones are, how they interact with each other and with DNA, and how they contribute to the compaction of DNA and gene regulation.

Answer 1

ANS) The main protein components of the chromatin that spools around DNA are known as Histones. Thus, the DNA and histones compress to form nucleosomes. Histones are composed of lysine and arginine and these are of five types Linker histones H1 and H5, and Core histones H2A, H2B, H3, and H4. Histones also play a major role in the regulation of genes,

Histones being positively charged bind with great force with negatively charged DNA for interaction between the proteins for formation of densely packed complexes. If not so the DNA would be in the form of long tails