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Which of the following is NOT a common mechanism for termination of receptor signaling? hydrolysis of...

Which of the following is NOT a common mechanism for termination of receptor signaling?

hydrolysis of second messengers

translational control of the receptor mRNA

receptor phosphorylation and desensitization

increasing the GTPase activity of the heterotrimeric G protein

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Answer #1

Answer: Choice 2

Reason: The receptor mRNA is required for synthesis of polypeptide which results in formation of the receptor protein in a cell. This phenomenal process is independent of the presence/absence of the receptor signalling since presence/abence of the receptor molecule does not interfere with intracellular signalling once the ligand has been bound to the receptor. Hence, the translational control of receptor mRNA is essential for generation of receptor, but not for the signalling mechanism mediated by it.

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