Question

Describe, in detail, a research question you could address using GenBank. Explain exactly how you would use GenBank to answer your question. If you would need information beyond what is in GenBank, explain what information. If not, explain why not

Answer 1

A child of 8 years (approx) is found with glucose intolerance and thus can not digest the D-glucose as the INSgene which codes for Insulin is mutated at the nucleotide level. Obtain the correct nucleotide sequence for the INSgene through GenBank and compare it with the mutated sequence. Find the mutated site (nucleotide base).

We have to submit the gene as INSgene in GenBank submission tool so we get the correct nucleotide sequence.

Also we can submit the sequence of the mutated gene of insulin and the GenBank will automatically identify the incorrect nucleotide sequence.

We need the information about the functions of the protein which is the translation product of the mutated gene. But the GenBank will not be useful in this direction because it takes only sequence submissions and it gives the protein product.