Question

A mutation results in the failure of fibroblasts to move to the site of infection. It is discovered that this mutation causes a particular protein to be absent, which leads to premature actin mRNA translation. Which protein is most likely absent due to the mutation?

CPEB

general transcription factor

ZBP1 (zip code-binding protein)

Src

Either Src or ZBP1

Answer 1

The correct option is

CPEB protein.

This protein represses the translation of the mRNA by regulating their closed-loop structure between the 3'UTR and 5'UTR which inhibits translation.

Other options are incorrect because:

General transcription factors do not bind to the mRNA but to the PROMOTER sequences in the DNA and increase transcription rate at these promoters.

ZBP1 protein interacts with DNA if present in the cytoplasm thus has antiviral activity of the cell. This is done on it's interaction with viral DNA the genes coding cytokines are transcribed to produce antiviral cytokines like interferon-Beta.

Src are the kinases which cause phosphorylation reactions which are involved in signal transduction.