Question

For each of the following engineered proteins, predict which location in the cell they would be...

For each of the following engineered proteins, predict which location in the cell they would be targeted to. Assume the following:

- Each targeting sequence is at the site along the protein (N terminus, C terminus, internal) where it would normally be found.

- Only targeting sequences possessed by each protein are those listed.

a) A cleavable ER-signal sequence and a stop transfer sequence (answer is not ER)

b) A peroxisomal sequence and a lysosomal signal sequence (answer is not lysosome)

c) No sorting signal (answer is not ER)

d) Multiple start and stop sequence signals (answer is not membrane of ER)

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Homework Answers

Answer #1

Protein synthesis takes place in the ribosomes which is present abundantly in cytoplasm and on rough endoplasmic reticulum.The amino acid sequence targets the ribosimes to attach to the ER membrane and according to the signal the polypeptide chain is cleaved and transferd to the ER lumen for further transfered with the help of rgoanelles,lysosomes,golgi bodies etc.

N terminal of the polypeptide sequence is always inside the ER limen and C terminal in the cytoplasm.

A)The clevable ER-signal sequence are targeted to lumen of endoplasmic reticulum and stop transfer sequence is targeted to membrane of endoplasic reticulum.

B)Peroxisome sequence in peroxisome matrix and lysosomal signal sequence in membrane of lysosomes.

c)No sorting signal -The protein with No sorting sugnel remains in he cytoplasm,.

D)Ribosomes on the membrane of rough endoplasmic reticulum.

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