Question

The National Pharmaceutical Company LLC has discovered a new Drug X. Early experiments show that this drug acts as an agonist on beta-adrenergic receptors with no effect on alpha-adrenergic receptors. Using this information, you are requested to write a report about Drug X to explain its pharmacological effects on the different tissues and organs and link it with the possible therapeutic uses of this drug as well as its adverse effects and contraindications.

Answer 1

Solution: Beta adrenergic receptor consists of different types such as alpha 1, alpha 2, beta 1, beta 2 and beta 3. All of these receptors are seven transmembrane GPCRs. One of the chief beta adrenergic receptor is a seven transmembrane G protein coupled receptor that in muscle binds to epinephrine molecules secreted by adrenal medulla and leads to the glycogen degradation into glucose. The Drug X designed here might act as beta adrenergic receptor binding agent. Binding of this drug inhibits the evoke of signal through this G protein coupled receptor. The agonists mainly act as smooth muscle contraction agent, increased cardiac effects, act as vassorepressor and also as bronchodialator. This drug may also induces increased glycogenolysis and lipolysis.