Q: List events of B cell maturation in the
spleen?
- B-lymphotcytes are a type of white blood cells which play an
important role in humoral immune response..
- The maturation process of B celll starts with B-cell precursors
present in the bone marrow (primary hematopoietic tissue). Self
reacting B-cells are first eliminated by negative selection. The
remaining ~10 % immature B-cells enters into bloodstream and
migrate to secondary lymphoid organ (spleen) for final stages of
maturation.
- Immature B cells express IgM and IgG on its surface whereas
mature B cells express IgM as well as IgD antibodies on its
surface.These migrated B cells are called transitional type 1 B
cells and these cells subsequently are developed into transitional
type 2 B cells. These two populations acts as a precursor for
mature B-cells. B cells that fail to mature die through apoptosis
mechanism.