Question

Why are sex chromosome aneuploidies more common than autosomal aneuploidies in humans?

Why are sex chromosome aneuploidies more common than autosomal aneuploidies in humans?

Homework Answers

Answer #1

Aneuploidy is the presence of abnormal number of chromosomes either 45 or 47 and not the usual 46 in humans.

In humans aneuploidy of sex chromosomes is more common than the aneuploidy of autosomes because humans have only one functional X-chromosome (both male and female). The other chromosome is inactive, so chances of survival are more when the other chromosome is inactivated than 2 X-chromosomes being active. This inactivation of one X-chromosome help in dose compensation. The individuals having sex chromosomes aneuploidy is better survived and so it is common. On the other hand autosomal aneuploidy is lethal.

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