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Among U.S. Caucasians, the frequency of the CF- allele causing the recessive autosomal disease cystic fibrosis...

Among U.S. Caucasians, the frequency of the CF- allele causing the recessive autosomal disease cystic fibrosis is 0.02. What is the Δq for the CF allele after one generation of random mating and selection?

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Answer #1

the CF- allele causing the recessive autosomal disease cystic fibrosis is 0.02 it indicates that out of 100 2 are suffering from disease. 98 are not affected. So here P = .98 and Q= .02

expectation of f(AA) = p2
expectation of f(Aa) =2pq

expectation of f(aa) = q2   
Hardy Weinberg states that allele and genotype frequencies in a population will remain constant from generation to generation in the absence of other evolutionary influences. hardy Weinberg is based on the principle of random mating. So, q for next generation will be .02 only

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