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The catechol system is important for the binding of adrenergic agonists, yet is not required for...

The catechol system is important for the binding of adrenergic agonists, yet is not required for adrenergic antagonists. Why should this be the case?

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The catechol system is important for the binding of adrenergic agonists, yet is not required for adrenergic antagonists :

Catecholamines undergo rapid degradation by monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT).

Consequently, they have a brief duration of action, and continuous infusion often is required to maintain the drug's effects.

Catecholamines cannot be used orally.

Catecholamines do not cross the blood-brain barrier; noncatecholamines do.

Noncatecholamines are not degraded by MAO.

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