Question

An individual is heterozygous for a chromosomal rearrangement. A normal chromosome and its aberrant homolog are...

An individual is heterozygous for a chromosomal rearrangement. A normal chromosome and its aberrant homolog are given below, where the dot represents the centromere:

Normal A B C.DEFGHI

Aberrant a fed.cbghi

If crossing over occurs between genes D and E, do you expect the gametes with the recombinant chromosomes to be viable? Explain why or why not.

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Answer #1

It is a pericentric inversion, in inversion heterozygote ,in order to have a point to point pairing across the length of the chromosome, an inversion loop is formed at the inverted region. In pericentric inversion because the centromeres are within the inverted region, the chromosomes that have crossed over disjoin in normal fashion without creation of bridge.Howeever they have duplication and deficiency for different parts of the chromosome.

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