Question

1. In fatty acid synthesis, Malonyl CoA is the activated form of acetyl CoA. What is the only chemical difference between these two molecules?

2. How many HMG-CoA are used to produce cholesterol

a. 4

b. 5

c. 6

d. 8

e. 18

Answer 1

ANSWER1
Although, both are derivatives of Co-A enzyme. Malonyl-CoA is 2-carbon unit where as acetyl-CoA is one carbon unit. Malonyl-CoA is syhthesised by carboxylation of acetyl-CoA in the presence of ATP. Synthesis of Malonyl-CoA is commitment step for fat synthesis and polyketides synthesis. Acetyl-CoA serves as intermediate in many chemical reactions. Acetyl CoA provides acetyl group in citric acid cycle to produce ATP and required for fatty acids breakdown.