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Spliceosome, a multimegadalton ribonucleoprotein (RNP) complex comprised of five snRNPs (small nuclear ribonucleoproteins) and numerous proteins. Spliceosomes are responsible for the removal of noncoding segments (introns) from pre-messenger RNAs (pre-mRNAs), a process critical for the maturation of eukaryotic mRNAs for subsequent translation by the ribosome.Two unique spliceosomes coexist in most eukaryotes 1. the U2-dependent spliceosome, which catalyzes the removal of U2-type introns, and 2. the less abundant U12-dependent spliceosome, which is present in only a subset of eukaryotes and splices the rare U12-type class of introns.
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