Question

In patients with type 2 diabetes, cells no longer respond to the hormone insulin. What change has likely occurred in these cells to make them insulin resistant?

Answer 1

Insulin is a hormone that signals the cells of the body to remove excess glucose (a sugar) from your bloodstream and store it in the cells.
The main source of energy for the body is Glucose.
It is important for the body, but excess of it can cause many complications.
There is no electron transfer mechanism for complex organic compounds like sugar when Cells become Resistant to Glucose.
and without Electron transfer mechanism, glucose cannot enter the cells.
It has been postulated that an increase in the intracellular concentration of fatty acid metabolites activates a serine kinase cascade, which leads to defects in insulin signaling downstream to the insulin receptor.