Question

Distinguish functional differences among basal factors, activators, and co-activators.

Answer 1

All are transcriptional factors and have different roles in gene transcription.

Basal factors	Activators	Co-activators
* basal factors are important proteins required for the activation of gene transcription * Basal factors are required by RNA polymerase II to form an initiation complex in transcription * eg: TFIIA	* Activators stimulate the xepression of a gene. * They acting at a promoter to stimulate the RNA polymerase binding * Eg : CAP	* Co activators increase the rate of transcription * They help the activators to interact with basal transcriptional factors Eg : CBP