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Calculate the energetic cost of nucleoside triphosphates consumed during one round of elongation after initiation is...

Calculate the energetic cost of nucleoside triphosphates consumed during one round of elongation after initiation is completed. Describe how the nucleoside triphosphate is used.

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Answer #1

One ATP is hydrolyzed during tRNA charging. This energy is stored in the acyl bond for peptide bond formation.

One GTP is hydrolyzed when EF-Tu dissociates from the ribosome after the correct codon/anticodon base pairing occurs between the codon and tRNA in the A site.

One GTP (carried by EF-G) is hydrolyzed during translocation.

Hydrolysis of the two GTP molecules is coupled to maintaining the order of the events of elongation and the specificity of that event (for EF-Tu).

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