Question

Please describe metabolic steps that can direct the carbons of palmitate to the uracil ring of uridine monophosphate.

Answer 1

Palmitate is converted to ATP in the first step by the process of beta-oxidation and in second step ATP is further converted to uridine monophosphate via multiple steps.

The steps involved in the conversion of ATP to uridine monophosphate is given below -

Here,

Ura1 is a bi-functional enzyme including carbamoyl phosphate synthetase I and aspartate transcarbamoylase,

Ura2 is dihydroorotase,

Ura3 is dihydroorotate dehydrogenase,

Ura5 is orotate phosphoribosyltransferase,

Ura4 is OMP decarboxylase.