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6. A particular disease is inherited in humans as an autosomal dominant. A survey in a...

6. A particular disease is inherited in humans as an autosomal dominant. A survey in a small country showed that, within a two-year period, there were 12 children with normal parents born with this disorder out of a total of 420,000 births. What is the mutation rate in mutations/locus/generation?

a.

1.4 X 10-5

b.

2.8 X 10-6

c.

2.8 X 10-5

d.

7.4 X 10-6

e.

2.5 X 10-5
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Answer #1

The particular disease is Autosomal Dominant.

There were 12 children with normal parents born with this disorder out of a total of 420,000 births within 2 years period.

So number of generation = 2

Now,

Mutation rate in mutations/locus/generation

=   Total number of children born with disorder    Total number of births × no. of generations

=

= 0.142 × 10^-4

= 1.42 × 10^-5

Thus the correct answer is (a) 1.42 × 10^-5 mutations/locus/generation.

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