Question

What is the role of Fc receptors in Antibody-Mediated (Type II) hypersensitivity reactions?

Answer 1

type 2 hypersensitivity is caused by antibodies binding to cells or tissue antigens. The antibodies are of the IgM and IgG classes and cause cell destruction by Fc dependent mechanism either directly or by recruiting complement via the classical pathway.

In complement mediated hypersensitivity reaction, the antibodies react with a cell membrane component with the help of Fc receptor , leading to complement activation and lysis of cell

Antibody dependent cell mediated cytotoxicity uses Fc receptors expressed on many cell types(NK cells, macrophages, neutrophils) as a means of bringing these cells into contact with antibody coated target cell