Question

Short Answer 5

What is one hypothesis for why children rarely get very sick from the coronavirus? How would you try to study this using your mouse model or other mice you might generate for this experiment.

Answer 1

One hypothesis for which children rarely get very sick from Corona virus is:

It could be that the type of T cell that dominates early in life is better at repelling this virus.

One explanation for the correlation between age and disease severity is that as humans’ immune systems age, more cells become inactive.

This can be studied using mouse model-

Findings in an experiment reported that T cells are especially important in clearing viruses from mice infected with SARS-CoV.

It is almost certain we need both an antibody- and T cell–response to do well, against COVID-19 infection

Young immune system and its efficient T cells do a superior job of responding to SARS-CoV-2.

Another study, also stressed the importance of CD4+ helper T cells, which stimulate B cells to make antibodies against pathogens, in controlling SARS-CoV infection in mice.

Ps- An upvote would be highly appreciated