Question

What is the difference between Prader Willy and Angelman syndromes?

Answer 1

They both involve genes that are located in the same region in the genome and are characterized by genetic imprinting
Prader Willy syndrome:
Paternal inheritance
It results when a baby inherits both copies of a section of chromosome 15 from the mother or even if both chromosomes are inherited normally the section of father's chromosome 15 is deleted.
When normally active copy of the gene or genes is missing, abnormality results.
Smal hands and feet , short stature
Mental retardation
Voracious appetite
Angelman Syndrome:
Maternal inheritance
When baby inherits both copies of a section of chromosome 15 from the father (rather than 1 from the mother, and 1 from the father). It also occurs if both chromosomes are inherited normally but a section of mother's chromosome is deleted.
Uncontrolled muscle movement
Very happy demenaor
Unusual seizures
Mental retardation