Question

A population of humans, isolated for centuries on an island in the Indian Ocean, exhibits the...

A population of humans, isolated for centuries on an island in the Indian Ocean, exhibits the following phenotypes for the M N blood group locus.

330 M

375 MN

295 N

LM and LN are two codominant alleles at this locus. LMLM alleles give type M blood. LMLN individuals are heterozygous. LNLN individuals are type N blood.

a) Using the Hardy-Weinberg equilibrium, calculate the expected frequencies of these blood types. Do a chisquare test of goodness of fit to compare observed and expected values. Is this population in Hardy-Weinberg equilibrium?

b) What might be going on here? What factors might cause a distribution of genotypes like this?

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Answer #1

Ans b

Whether population is at equilibrium for a gene with alleles is determined by studying the random samples, individuals in sample are classified into the three genotypes possible for the gene and frequencies of the two alleles of the gene. In this type of genotype, Hardy Weinberg equilibrium law does not exists and chi- square test is also non-significant at p value 0.05.

The equilibrium can be disturbed by migration, mutation, selection and genetic drift., in which frequencies of the three genotypes gets deviate from p2,MM., q2 NN and 2pq MN.

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